Epileptic confusion in the elderly : a 1-year prospective study / Olivier Véran ; sous la direction de Laurent Vercueil

Date :

Type : Livre / Book

Type : Thèse / Thesis

Langue / Language : anglais / English

Langue / Language : français / French

Troubles de la cognition -- Chez la personne âgée

État de mal épileptique -- Diagnostic

Électroencéphalographie

État de mal épileptique -- Dissertation universitaire

Classification Dewey : 610

Vercueil, Laurent (1965-.... ; neurologue) (Directeur de thèse / thesis advisor)

Kahane, Philippe (1962-.... ; neurologue) (Président du jury de soutenance / praeses)

Université Joseph Fourier (Grenoble, Isère, France ; 1971-2015) (Organisme de soutenance / degree-grantor)

Relation : Epileptic confusion in the elderly : a 1-year prospective study / Olivier Véran ; sous la direction de Laurent Vercueil / Grenoble : Université Grenoble Alpes , 2024

Résumé / Abstract : Background: Since nonconvulsive status epilepticus (NCSE) is clinically difficult to diagnose, especially in old patients without epilepsy, and requires EEG for diagnosis, its incidence among elderly patients with confusion of unknown origin (CUO) remains undetermined. Methods: After a pilot study, we conducted a 1-year prospective study in patients aged 60 years or more, for whom an EEG was requested because of confusion considered to be of unknown origin after initial biological and imaging investigations. Diagnosis criteria included the validated clinical assessment scale to confirm confusion. Results: Out of 44 patients, seven presented with de novo NCSE. The NCSE population had a mean age of 76 years (range, 60–97). No statistically significant differences were found between NCSE and non-NCSE patients for age, drugs, myoclonia, eyelid myoclonia, tachycardia, or agitation. In contrast, an acute onset, gender (100% female among NCSE patients), and lack of clinical response to simple commands were significantly associated with NCSE. No differences between the two groups were evidenced for mortality and morbidity (length of hospitalization, social outcome, etc.).